Changes
Giving up the old way of doing things (Iwata Airbrush vs Wacom Cintiq).
I've been airbrushing for over 25 years now but for the last six mounts I haven't even looked at my trusty old Iwata airbrush. I recently picked up a Cintiq 21ux by Wacom to replace my Intuo3, this thing is simply amazing! You can use most of the same techniques you would with traditional tools without slowing down and now with Adobes Photoshop CS5 the brush handling is even tighter...
A couple years ago I couldn't imagine not having an airbrush as part of my tool set. But the more I use this drawing tablet the more I'm thinking I'll most likely never use my airbrush again. I just don't see a need for it any longer.